When an obese 10-year-old girl presents with a heart attack, House and his team investigate. At first thinking it’s an adverse reaction to diet pills, they ultimately uncover a much more deadly source of her illness.

Meanwhile, under pressure from hospital management, House tries to figure out which of his team to fire. But once he makes a decision, Vogler doesn’t accept it and demands he pick someone else, leading House to suspect one of his team members is giving inside information to Vogler.